In 2012, Patra unsuccessfully fought a municipal election as BJP’s candidate from Delhi’s Kashmere Gate and at the same time resigned from his job to pursue politics as his full time passion. Much before the election, in the year 2010, he was appointed as the spokesperson for Delhi unit of BJP. In the run-up to the Lok Sabha elections in 2014, he campaigned for BJP and gained visibility on national television. When BJP rose to power, Dr. Sambit Patra became its national spokesperson. Dr. Sambit Patra represents the state of Odisha in the central committee of BJP, chaired by National President Amit Shah. He's the founder of NGO Swaraj which comprises Doctors and Policemen from all over India, an NGO working for the emancipation of Dalits. He played central role in getting the words "chamar", "harijan" etc. removed from caste certificates issued by Delhi government.